A Well Styled Life® a registered trademark. I don’t take those supplements you’re taking. The following is a list of ingredients that Estrovera supplements contain: 1. Here you'll find style tips and lifestyle inspiration to help you dress with confidence so you can live your best life over 50. It contains an exclusive phytoestrogenic extract of rhapontic (Siberian) rhubarb root known as ERr 731® that has been suggested to be comparable in effectiveness to an ultra low dose of conventional hormone therapies. Non-Alcoholic Fatty Liver Disease. This plant-based supplement has been shown to be a safe and effective option for women dealing with menopause. Liver Disease. 2008;14(6):32-38. For those not interested in research, feel free to skip the next few paragraphs and go on to our conclusion. ERr 731 siberian rhubarb (Rheum rhaponticum L.) extract (root) [std. 2006;13(5): 744-59. Required fields are marked *. After 12 weeks, a reduction in the severity of anxiety from "moderate" or "severe" to "slight" was observed in 33 of 39 ERr 731 women completing the double-blind phase, which correlated well with the reduction in number and severity of hot flushes. I thought these would be gone by now but they just keep coming. ERr 731 has been professionally recommended for over 20 years with no serious adverse events reported and no clinically relevant changes in safety parameters have been observed in clinical trials. I can’t wait to hear how you feel at the 12 week mark! Croscarmellose Sodium 4. Unauthorized use and/or duplication of any images or written material is strictly prohibited without express and written permission from this blog's author and owner. to > 54% rhaponticin, > 27% desoxyrhaponticin] 4mg Other ingredients: microcrystalline cellulose, stearic acid, croscarmellose sodium, silica, enteric coating (ethylcellulose, sodium alginate, medium chain triglycerides, oleic acid). Rhapontic Root: An extract from the Siberian rhubarb plant, that various studies have proven is ideal for curing hot flashes 2. Heaven Bound. Report abuse. Download the PDF. 10 people found this helpful. Results: After 6 months of treatment with ERr 731 in 252 women, there was a significant decrease of the MRS total score from 14.5 points at baseline to 6.5 points (P<.0001). A decrease in climacteric complaints, a high satisfaction with treatment, and no unwanted side effects by an up to 2 year intake of ERr 731 were shown confirming that ERr 731 can be … Your email address will not be published. The efficacy of ERr 731(®), a commercially available extract isolated from Rheum rhaponticum, in terms of menopausal complaints like hot flushes, depression, anxiety and vaginal dryness has been proven in a two-year clinical study. Thanks for reading ladies and have a great day! Consequently, menopausal women, who often require relief over several years, can take ERr 731 in its proposed indication of No side negative effects. My sleep disturbances, occasional hot flashes, and joint discomfort are all things I’m hoping Menopause 731™  can help ease. Efficacy and safety of a special extract of Rheum rhaponticum (ERr 731) in perimenopausal women with climacteric complaints: a 12-week randomized, double-blind, placebo-controlled trial. Available at: http://www.menopause-rating-scale.info/evaluation.htm. Accessed July 3, 2018. 3. One customer reported of kidney failure after using rhubarb. This post is sponsored by Life Extension. In a clinical trial of 232 people, A Chinese herbal … So, what side effects can Rhubarb cause? Similarly, ERr 731 showed no agonist activity when tested in the HEC-1B endometrial cancer cells transfected with ERα.16On ERβ, the activi- ty of ERr 731 is comparable to that of 10-8M E2, and thus, it appears likely that ERr 731 mediates its benefi cial effects on menopausal symptoms such as hot fl ushes, depression, and anxiety at least in part via its ERβ-selective properties. Stearic Acid(saturated fatty acid): Derived from many vegetable and animal oil and fats. ERr 731® is an extensively researched, natural approach for hot flash relief. Clinically shown to dramatically reduce the number of daily hot flashes and relieve a wide range of other symptoms. Demonstrated to relieve hot flashes to a similar extent as estrogen-based therapies and exceed reported results of other phytoestrogen and botanical approaches. The key ingredient in Estrovera is a phyto-estrogen from the Siberian rhubarb plant known as ERr 731. Or if it would replace all those other things I’m currently taking to ease my hot flashes and sleep issues. Post was not sent - check your email addresses! Aging has its own challenges, but add menopause to the mix and the struggle is real. Long-term use or use in higher doses can lead to bone loss, muscular weakness, irregular heart rhythm, and potassium loss. A recent clinical study with a two-year application of the extract ERr 731® from Rheum rhaponticum demonstrated its efficacy and potentially suggested it safety regarding unwanted endometrial side effects. When I was invited to try Menopause 731™ by Life Extension® for 30-days and share my experience with you, I agreed because other methods are not an option for me. The active ingredient in Estroven ® Complete Menopause Relief, rhubarb extract ERr ® 731, selectively stimulates the ERβ. ERr 731® is a registered trademark of Chemisch-Pharmazeutische Fabrik Göppingen Carl Müller Apotheker GmbH & Co. Comment document.getElementById("comment").setAttribute( "id", "adf71b2f8bc431815793c6fa12d34376" );document.getElementById("c6afaf38a7").setAttribute( "id", "comment" ); Welcome to A Well Styled Life, your online destination for fashion, beauty, and wellness. 2. Now at four weeks I know it’s helping. ERr 731 ® siberian rhubarb (Rheum rhaponticum L.) extract (root) [std. Please check with your doctor if you have concerns or questions and y. Search. Rhubarb can cause some side effects such as stomach and intestinal pain, watery diarrhea, nausea, vomiting, rash, and uterine contractions. Today I’m sharing my results of using a nutritional supplement to get some relief for my nagging menopause discomforts. It's not entirely clear how ERr 731 performs its actions in the body, write the researchers. Your email address will not be published. I know my husband is hoping my mood swings ease up too;). ERr 731 (Extract Rheum rhaponticum), derived from the roots of rhubarb plants, has clinical proof that it equals the symptom relief of hormone replacement therapy with a side effect profile better than a placebo. Main Ingredients. Effects of the special extract ERr 731 from Rheum rhaponticum on estrogen-regulated targets in the uterotrophy model of ovariectomized rats. The efficacy of ERr 731(®), a commercially available extract isolated from Rheum rhaponticum, in terms of menopausal complaints like hot flushes, depression, anxiety and vaginal dryness has been proven in a two-year clinical study. to > 54% rhaponticin, > 27% desoxyrhaponticin] 4 mg Other ingredients: microcrystalline cellulose, stearic acid, croscarmellose sodium, silica, enteric coating (ethylcellulose, sodium alginate, medium chain triglycerides, oleic acid). Menopause. It helped with my sleep but wasn’t earth-shattering for my joints. This plant-based supplement has been shown to be a safe and effective option for women dealing with menopause. It’s already helping so I assume it can only get better. Menopause 731™ uses a clinically studied extract of Siberian rhubarb ( R. rhaponticum) root to address 11 common menopausal discomforts: hot flashes, night sweats, irritability, mood swings, sleep disturbances, exhaustion, joint and muscle discomfort, vaginal … Please check with your doctor if you have concerns or questions and you can learn more about Menopause 731™  here. Thank you. J Steroid Biochem Mol Biol. Heaven Bound. It’s definitely worth a try because there are no side effects and our bodies are all unique. I suppose it’s now been 20 weeks— are you still using it? Helpful. ERr 731 has been professionally recommended for over 20 years with no serious adverse events reported and no clinically relevant changes in safety parameters have been observed in … Report abuse. Unlike common Rhubarb, the standardized, patented extract ERr 731 ® contains the important compounds rhaponticin and desoxyrhaponticin shown to alleviate menopause symptoms. Altern Ther Health Med. ERr 731 is distributed abroad exclusivly by HRS. These statements have not been evaluated by the Food and Drug Administration. ERr 731 is effective and safe in the long-term treatment of menopausal symptoms in perimenopausal women. Thanks to Life Extension for partnering on this post. Can you advise what other supplements you are taking? Heger M, et al. I’m sleeping more soundly and so is my husband! Long-term use … At the three week mark, I thought I noticed an improvement in my sleep but couldn’t be sure. 12-week randomized controlled trial (RCT) 109 perimenopausal women. Heger M, Ventskovskiy BM, Borzenko I, et al. Stimulation of ERβ has been shown to elicit beneficial estrogen-like activities and reduce adverse side effects. 5.0 out of 5 stars Worked for me! ... Further a recent preclinical study excluded unwanted side effects on the endometrium by showing a lack of st Sort by. A recent clinical study with a two-year application of the extract ERr 731 from Rheum rhaponticum demonstrated its efficacy and potentially suggested it safety regarding unwanted endometrial side effects. Filter by All ... which is the same thing- 4 mg ERr 731, 21 people found this helpful. Please share how you sleep by thevone-month mark. ERr 731 demonstrates selective affinity for ERß, in endometrial tissue, which suggests a safer approach. 2009; 117(4-5):176-84 … Reviewed in the … Menopause 731 ™ is a unique Siberian rhubarb extract which selectively activates ER-β, a specific estrogen receptor and offers a non-hormonal approach to easing the discomforts of menopause. The worldwide unique product ERr 731 from siberian rhubarb for women in menopause produced exclusively by Mueller Goeppingen and distributed by HRS to the World. I’m pretty close to that now so can only assume it will keep improving. Rhubarb Reduces Hot Flashes. Happy Friday ladies. Menopause. Long-term effects of the rhapontic rhubarb extract ERr 731® on estrogen-regulated targets in the uterus and on the bone in ovariectomized rats. Amazon's price is super user friendly compared to Estrovera, which is the same thing- 4 mg ERr 731, 21 people found this helpful. I’ll let you know. I’ve added glucosamine for that and hope it will help. 10 people found this helpful. I would love to give it a try ! Further a recent preclinical study excluded unwanted side effects on the endometrium by showing a lack of stimulation of proliferation marker genes by ERr 731 ® or its … Thus, nei-ther laxative nor other effects are associated with the plant or the spe-cial extract. Tina Marie. The extract, known as ERr 731, doesn’t contain estrogens. Kaszkin-Bettag M, Beck S, Richardson A, Heger PW, Beer AM. I’m trying to understand if this can be taken along with Black Cohosh, Soy, and Melatonin? 5.0 out of 5 stars Worked for me! Rhapontic Rhubarb extract (ERr 731 ®) is a patented botanical ingredient that has been used in Germany since the 1950’s for relief from menopausal symptoms and is now available in the US. Report abuse. It’s just one tiny pill a day that I take the same time as my other supplements. Moreover, women who took the ERr 731 experienced no vaginal bleeding and spotting which are common side effects due to an estrogen-dependent stimulation of the endometrium, nor was there any evidence of endometrial hyperplasia in the treated women. Jennifer, how did the Menopause 731 work for your sleep and joints after 12 weeks? ... No side negative effects. Siberian rhubarb root extract (ERr 731®) - originating from eastern Europe, a phytoestrogen proven to reduce the frequency and severity of menopausal symptoms Other Ingredients. Potential estrogenic effects on the uterine gene expression were tested after treatment of rats with two doses of ERr 731 ® over a 90-day period. This product is not intended to diagnose, treat, cure, or prevent any disease. Top reviews. At 12 weeks, ERr 731® group had a significant reduction in total Menopause Rating Scale II (MRS II) score, as well as significant decreases in all 11 individual symptom scores compared with placebo (p<0.001) No abnormalities in safety parameters such as … The efficacy of ERr 731 ®, a commercially available extract isolated from Rheum rhaponticum, in terms of menopausal complaints like hot flushes, depression, anxiety and vaginal dryness has been proven in a two-year clinical study. The special extract from the roots of Rheum rhaponticum (L.), referred to as ERr 731[R] (trade name Phytoestrol[R] N), has been regularly prescribed for climacteric complaints since 1993, without the occurrence of any safety related side effects such as endometrial hyperplasia, spotting or breakthrough bleeding. Efficacy of the special extract ERr 731 from rhapontic rhubarb for menopausal complaints: a 6-month open observational study. One can suffer from stomach and intestinal pain, uterine contractions, and watery diarrhea. Has ch… Thanks for sharing your observations with us! I take tons of supplements daily. I haven’t slept through the night for a very long time and my tossing and turning means my husband hasn’t either. We’re both thrilled. 2006. Sorry, your blog cannot share posts by email. ther the roots of R rhaponticum nor the special herbal extract ERr 731 of the roots contains any emodin, aloe-emodin, or rhein. Microcrystalline Cellulose (refined wood pulp): Provides dietary bulk and lends aid in reducing tension and anxiety. Estrovera’s key ingredient, ERr731, has been used safely and effectively for over 20 years and is supported by clinical studies. Germany for over 15 years. The other reason I agreed to try it is because I found many double-blind, placebo-controlled human studies which show that Siberian Rhubarb extract significantly reduces 11 menopausal discomforts – hot flashes, night sweats, irritability, mood swings, sleep disturbances, exhaustion, joint and muscle discomfort, vaginal dryness, urinary health, and sexual function. ERr 731 also reduced the Hamilton Anxiety Scale factor scores for somatic and psychic anxiety. * References 1. I do take melatonin and valerian to help me sleep as well. The reduction of the MRS score was more pronounced in women with a score of > or =18 points at baseline. Read more. 1. 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